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modafinil will lower the extent or outcome of pacritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Impact of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been analyzed.steroid hormones, which include estradiol, progesterone or cortisol. Modafinil might have an adverse effect on hormo